Prevalence of multi drug resistant Acinetobacter baumannii in the clinical samples from Tertiary Care Hospital in Islamabad, Pakistan
نویسندگان
چکیده
BACKGROUND & OBJECTIVES Acinetobacter baumannii can cause a wide range of infections, including bacteremia, pneumonia, urinary tract infection, peritonitis, etc. This organism is becoming resistant to a large group of antibiotics, especially β-lactam antibiotics. The reason for multi-drug resistance may be the production of extended- spectrum β-lactamses (ESBLs), carbapenemases/metallo β-lactamases or AmpC β-lactamases. The aim of the present study was to determine the prevalence of multi-drug resistant Acinetobacter baumannii isolated from the patients in Surgical Intensive Care Units (SICUs) of Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan. METHODS A total of 91 A. baumanni isolates were collected from PIMS during the period from February 2011 to December 2011. The antibiotic susceptibility testing was performed by standard disc diffusion method as recommended by CLSI. Combination disc method, Modified Hodge test, EDTA disc synergy test and AmpC disc test were performed for detection of ESBLs, carbapenemases, metallo β-lactamases, and AmpC β-lactamases, respectively. RESULTS The prevalence of MDRs was reported 100% among A. baumannii. The antibiotic susceptibility profile showed that minocycline and tigecycline were the most effective drugs against A. baumannii. Almost all of A. baumannii isolates were carbapenemase and metallo β-lactamase producers. AmpC prevalence was observed in 41.76%, while none of the isolates was ESBL producer. Antibiogram and minimal inhibitory concentrations (MICs) indicated tetracycline is relatively effective against A. baumanii. CONCLUSIONS Increased frequency of multi-drug resistance supports the need for continuous surveillance to determine prevalence and evolution of these enzymes in Pakistan.
منابع مشابه
Antimicrobial Resistance Pattern of Acinetobacter baumannii Strains Isolated from Intensive Care Unit Patients
ABSTRACT Background and Objectives: Acinetobacter baumannii is an opportunistic pathogen that affects different groups of people, especially intensive care unit (ICU) patients. The prevalence of infections caused by this bacterium is very high. Today, prevalence of infections caused by multidrug-resistant (MDR) and extreme-drug resistant (XDR) strains is increasing. This study aime...
متن کاملPrevalence of Drug Resistance in Nonfermenter Gram-Negative Bacilli
Background and Objectives: Non-fementer gram-negative bacilli (NFGB) are ubiquitous pathogen that has emerged as a major cause of health care associated infections. The aim of this study was to determine the prevalence and antimicrobial susceptibility of NFGB in an Iranian hospital. Materials and Methods: FromJuly 2005 to November 2006 a total of 257 strains of NFGB including 109 (42.41%)...
متن کاملPrevalence of Extended Spectrum Beta Lactamases (ESBLs) and Antibiotic Resistance Pattern Acinetobacter Baumannii Strains Isolated from Clinical Specimens in Isfahan City, Iran
Abstract Background and Objective: Acinetobacter species are opportunistic important pathogens responsible for many nosocomial infections. The purpose of this study was to determine the drug resistan pattern Acinetobacter baumannii and prevalence of ESBL producing strains in Intensive Care Unit patients in Isfahan city hospitals. Material and Methods: The study was conducted on 100 Ac...
متن کاملAntimicrobial Resistance Pattern of Stenotrophomonas maltophilia Isolates from a Tertiary Care Setting in Rawalpindi, Pakistan
Introduction: Stenotrophomonas maltophilia is intrinsically resistant to many antimicrobials. Like Pseudomonas spp., this bacterium has a remarkable ability to cause infections, particularly in the respiratory and urinary tracts. This study aims to determine the antimicrobial resistance pattern of S. maltophilia isolates collected from a tertiary care setting and frequency of multi, extensively...
متن کاملEvaluation of growth inhibition activity of myxobacterial extracts against multi-drug resistant Acinetobacter baumannii
The worldwide dissemination of multi drug resistant Acinetobacter baumannii strains has caused serious concern and high rate of mortality in recent decades that originate from limited effective antibiotics in the treatment of A. baumannii infections. Myxobacteria are Gram-negative bacteria that are important for their complex lifestyle and production of novel structurally secondary metabolites ...
متن کامل